This book summarizes the works and new research results presented at the First International Symposium on Intelligent Interactive Multimedia Systems and Services (KES-IIMSS 2008), organized by the University of Piraeus and its Depa- ment of Informatics in conjunction with KES International (Piraeus, Greece, July 9-11, 2008). The aim of the symposium was to provide an internationally respected forum for scientific research into the technologies and applications of intelligent int- active multimedia systems and services. Besides the Preface, the book contains sixty four (64) chapters. The first four (4) chapters in the book are printed versions of the keynote addresses of the invited speakers of KES-IIMSS 2008. Besides the invited speaker chapters, the book contains fifteen (15) chapters on recent Advances in Multimedia Data Analysis, eleven (11) chapters on Reasoning Approaches, nine (9) chapters on Infrastructure of Intelligent Interactive Multimedia Systems and Services, fourteen (14) chapters on Multimedia Applications, and eleven (11) chapters on Quality of Interactive Multimedia Services. von Tsihrintzis, George A.