Providing a spectrum of models that is reflective of the various species that can be utilized in experimentation on disorders across a broad range of developmental disabilities, this volume collects expert contributions involved in investigation of the causes, outcomes, treatment, and prevention. Animal Models of Neurodevelopmental Disorders explores models of perinatal hypoxia-ischemia/cerebral palsy and stroke, autism spectrum disorder, fetal alcohol syndrome, as well as mental retardation. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Practical and authoritative, Animal Models of Neurodevelopmental Disorders serves to introduce and entice those interested in better understanding and treating these disorders to the vital animal model world of investigation. von Yager, Jerome Y.
Series PrefacePrefaceContributors 1. Unilateral Common Carotid Artery Ligation as a Model of Perinatal Asphyxia: The Original Rice-Vannucci Model Antoinette Nguyen, Edward A. Armstrong, and Jerome Y. Yager 2. Bilateral Uterine Artery Ligation (BUAL): Placental Insufficiency Causing Fetal Growth Restriction and Cerebral Palsy Jennifer Corrigan, Edward A. Armstrong, Stuart Faulkner, Crystal A. Ruff, Michael Fehlings, and Jerome Y. Yager 3. Perinatal Intracerebral Hemorrhage Model and Developmental Disability Janani Kassiri and Marc R. Del Bigio 4. Rabbit Kit Model of Glycerol-Induced Intraventricular Hemorrhage Praveen Ballabh 5. Models of Perinatal Brain Injury in Premature and Term Newborns Resulting from Gestational Inflammation Due to Inactivated Group B Streptococcus (GBS), or lipopolysaccharide (LPS) from E. coli and/or Immediately Post-Natal Hypoxia-Ischemia (HI) Julie Bergeron, Marie-Julie Allard, Clémence Guiraut, Mathilde Chevin, Alexandre Savard, Djordje Grbic, Marie-Elsa Brochu, and Guillaume Sébire 6. Fetal Brain Activity in the Sheep Model with Intra-Uterine Hypoxia Bryan S. Richardson and Brad Matushewski 7. Studies of Perinatal Asphyxial Brain Injury in the Fetal Sheep Paul Drury, Laura Bennet, Lin Booth, Joanna Davidson, Guido Wassink, and Alistair Jan Gunn 8. The Sheep as a Model of Brain Injury in the Premature Infant Stephen A. Back, Art Riddle, and A. Roger Hohimer 9. The Rabbit as a Model of Cerebral Palsy Kehuan Luo, Jessica Baker, Matthew Derrick, and Sidhartha Tan 10. A Newborn Piglet Survival Model of Post-Haemorrhagic Ventricular Dilatation (PHVD) Kristian Aquilina and Marianne Thoresen 11. Physiologic Aspects of the Piglet as a Model of Perinatal Hypoxia and Reoxygenation Richdeep S. Gill, David L. Bigam, and Po-Yin Cheung 12. The Newborn Pig Global Hypoxic-ischemic Model of Perinatal Brain and Organ Injury Elavazhagan Chakkarapani and Marianne Thoresen 13. Animal Models of Fetal Alcohol Spectrum Disorder Wendy Comeau, Tamara Bodnar, Kristina Uban, Vivian Lam, Kasia Stepien, and Joanne Weinberg 14. Modeling Mental Retardation in Drosophila Francois V. Bolduc 15. Animal Models of Cerebral Dysgenesis: Excitotoxic Brain Injury Luigi Titomanlio, Leslie Schwendimann, and Pierre Gressens 16. The Effect of Age on Brain Plasticity in Animal Models of Developmental Disability Bryan Kolb and Deborah Saucier
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