Massimo Leone has been a neurologist at Carlo Besta Neurological Institute since 1985. Throughout the years he has helped to introduce the main treatments for cluster headache and other trigeminal autonomic cephalgias, including verapamil. He has been recognized by various Institutions for the introduction of deep brain stimulation in cluster headache and other trigeminal autonomic cephalgias, and has published 270 original articles. Since 2007 he has led the Neuromodulation Unit of the Neurological Department, Headache and Neuroalgology Centre at Carlo Besta Neurological Institute. Arne May is a Professor of Neurology at the Department of Systems Neuroscience, University of Hamburg and head of the headache outpatient clinic and the facial outpatient clinic of the University Clinic of Hamburg. His major research interests are the basic mechanisms of facial and head pain, the chronification of pain and plasticity within the human brain. His group's work involves humanimaging studies in primary headache as well as experimental studies of trigeminovascular nociception, with the aim of understanding how to modulate facial and headache syndromes and chronicity of pain. Prior to his position at the University of Hamburg, Professor May was a clinician and conducted research on pain and headache syndromes at the University of Regensburg. Prior to this he completed his residency in the Neurology Department of the University of Essen, followed by post-doctorate studies at the Institute of Neurology in London. Professor May has been a member of the Board of Trustees of the International Headache Society since 2013, and has published over 300 original and review articles.