
Cancer Biology and the Nuclear Envelope
Kurzinformation



inkl. MwSt. Versandinformationen
Artikel zZt. nicht lieferbar
Artikel zZt. nicht lieferbar

Beschreibung
"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer." von Schirmer, Eric und Heras, Jose de las
Produktdetails

So garantieren wir Dir zu jeder Zeit Premiumqualität.
Über den Autor
Eric C. Schirmer, Ph.D., Wellcome Trust Senior Research Fellow, Wellcome Trust Centre for Cell Biology and Reader, Institute of Cell Biology at the University of Edinburgh. Jose de las Heras Ph.D., Researcher at the University of Edinburgh.
- hardcover
- 4070 Seiten
- Erschienen 2011
- Springer
- Gebunden
- 412 Seiten
- Erschienen 2010
- Humana
- Gebunden
- 561 Seiten
- Erschienen 2022
- Thieme
- hardcover
- 821 Seiten
- Erschienen 2002
- McGraw Hill Higher Education
- Hardcover
- 416 Seiten
- Erschienen 1999
- Mariner Books
- Gebunden
- 278 Seiten
- Erschienen 2011
- Springer
- Hardcover -
- Erschienen 2011
- Wiley-Blackwell
- perfect
- 168 Seiten
- Erschienen 1979
- Fischer Verlag
- hardcover
- 666 Seiten
- Erschienen 1998
- Blackwell Science Inc.
- hardcover
- 860 Seiten
- Erschienen 2007
- Elsevier Books
- Kartoniert
- 630 Seiten
- Erschienen 2019
- De Gruyter
- Kartoniert
- 748 Seiten
- Erschienen 2011
- Humana
- Gebunden
- 1280 Seiten
- Erschienen 2016
- WH Freeman
- Kartoniert
- 1404 Seiten
- Erschienen 2022
- Norton & Company
- Hardcover
- 192 Seiten
- Erschienen 2013
- Springer